Malignant Tongue Neoplasm
Associated Genetic Biomarkers
NCI Definition: A malignant neoplasm affecting the tongue. The vast majority of cases are carcinomas. 
Malignant tongue neoplasms most frequently harbor alterations in TP53, RXRA, PRKCI, MDM2, and FGF4 .
TP53 X307_splice, RXRA R371H, PRKCI G449R, MDM2 Amplification, and FGF4 Amplification are the most common alterations in malignant tongue neoplasm .
There is 1 clinical trial for malignant tongue neoplasm, of which 0 are open and 1 is completed or closed. Of the trial that contains malignant tongue neoplasm as an inclusion criterion, 1 is phase 1/phase 2 (0 open).
CDKN2A and HPV are the most frequent gene inclusion criteria for malignant tongue neoplasm clinical trials .
Aminolevulinic acid and photodynamic therapy are the most common interventions in malignant tongue neoplasm clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.