NCI Definition: A malignant neoplasm affecting the tongue. The vast majority of cases are carcinomas. [1]

Malignant tongue neoplasms most frequently harbor alterations in TP53, RXRA, PRKCI, MDM2, and FGF4 [2].

Most Commonly Altered Genes in Malignant Tongue Neoplasm

TP53 X307_splice, RXRA R371H, PRKCI G449R, MDM2 Amplification, and FGF4 Amplification are the most common alterations in malignant tongue neoplasm [2].

Top Alterations in Malignant Tongue Neoplasm

Disease Details

Malignant Neoplasm of Tongue, Malignant Tumor of the Tongue, Tongue Neoplasm Malignant Stage Unspecified, Tongue Cancer, Tongue Neoplasm, Malignant, Malignant Neoplasm of the Tongue, Malignant Tumor of Tongue, Malignant Tongue Tumor
Tongue Disorder
Tongue Squamous Cell Carcinoma and Tongue Adenosquamous Carcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.