Overview

NCI Definition: Abnormal malignant growth of cells in the urethra (lower urinary tract). [1]

Malignant urethral neoplasms most frequently harbor alterations in TP53, FGFR3, PIK3CA, CDKN2A, and KDM6A [2].

Most Commonly Altered Genes in Malignant Urethral Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, FGFR3 Mutation, and TP53 Exon 8 Mutation are the most common alterations in malignant urethral neoplasm [2].

Top Alterations in Malignant Urethral Neoplasm

Significant Genes in Malignant Urethral Neoplasm

ERBB2 +

Disease Details

Synonyms
Urethra Cancer, Malignant Urethra Tumor, Malignant Tumor of the Urethra, Malignant Neoplasm of the Urethra, Malignant Urethral Tumor, Malignant Neoplasm of Urethra, Malignant Urethra Neoplasm, Urethral Cancer, Malignant Tumor of Urethra
Parent(s)
Urethral Neoplasm
Children
Mucosal Melanoma of the Urethra, Paraurethral Gland Cancer, Urethral Carcinoma, Female Urethral Malignant Neoplasm, Male Urethral Malignant Neoplasm, Anterior Urethral Malignant Neoplasm, and Posterior Urethral Malignant Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.