NCI Definition: Abnormal malignant growth of cells in the urethra (lower urinary tract). [1]

Malignant urethral neoplasms most frequently harbor alterations in TP53, PIK3CA, KDM6A, CDKN2A, and NF1 [2].

Most Commonly Altered Genes in Malignant Urethral Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KDM6A Mutation, and CDKN2A Loss are the most common alterations in malignant urethral neoplasm [2].

Top Alterations in Malignant Urethral Neoplasm

Disease Details

Malignant Tumor of the Urethra, Urethral Cancer, Malignant Tumor of Urethra, Malignant Neoplasm of the Urethra, Malignant Neoplasm of Urethra, Malignant Urethra Tumor, Malignant Urethral Tumor, Malignant Urethra Neoplasm, Urethra Cancer
Urethral Neoplasm
Anterior Urethral Malignant Neoplasm, Male Urethral Malignant Neoplasm, Posterior Urethral Malignant Neoplasm, Urethral Carcinoma, Female Urethral Malignant Neoplasm, Paraurethral Gland Cancer, and Mucosal Melanoma of the Urethra


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.