Overview

NCI Definition: A malignant neoplasm that affects the uterine corpus. Representative examples include endometrial carcinoma, carcinosarcoma, leiomyosarcoma, and adenosarcoma. [1]

Malignant uterine corpus neoplasms most frequently harbor alterations in TP53, PTEN, PIK3CA, ARID1A, and PIK3R1 [2].

Most Commonly Altered Genes in Malignant Uterine Corpus Neoplasm

PIK3CA Mutation, TP53 Mutation, PTEN Mutation, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in malignant uterine corpus neoplasm [2].

Top Alterations in Malignant Uterine Corpus Neoplasm

Disease Details

Synonyms
Malignant Tumor of Uterine Body, Malignant Neoplasm of Uterine Body, Malignant Corpus Uteri Neoplasm, Malignant Uterine Body Neoplasm, Malignant Tumor of the Uterine Body, Malignant Uterine Body Tumor, Malignant Neoplasm of the Uterine Body, Malignant Corpus Uteri Tumor, Malignant Uterine Corpus Tumor
Parent(s)
Uterine Corpus Neoplasm
Children
Uterine Corpus Choriocarcinoma, Uterine Corpus PEComa, Stage 0 Uterine Corpus Cancer AJCC v6, Malignant Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm, Malignant Endometrial Neoplasm, Uterine Corpus Sarcoma, and Uterine Corpus Carcinosarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.