NCI Definition: A malignant neoplasm that affects the uterine corpus. Representative examples include endometrial carcinoma, carcinosarcoma, leiomyosarcoma, and adenosarcoma. [1]

Malignant uterine corpus neoplasms most frequently harbor alterations in TP53, PTEN, PIK3CA, ARID1A, and PIK3R1 [2].

Most Commonly Altered Genes in Malignant Uterine Corpus Neoplasm

PIK3CA Mutation, TP53 Mutation, PTEN Mutation, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in malignant uterine corpus neoplasm [2].

Top Alterations in Malignant Uterine Corpus Neoplasm

Disease Details

Malignant Tumor of Uterine Body, Malignant Tumor of the Uterine Body, Malignant Corpus Uteri Neoplasm, Malignant Corpus Uteri Tumor, Malignant Neoplasm of Uterine Body, Malignant Uterine Corpus Tumor, Malignant Uterine Body Tumor, Malignant Uterine Body Neoplasm, Malignant Neoplasm of the Uterine Body
Uterine Corpus Neoplasm
Uterine Corpus Malignant PEComa, Uterine Corpus Choriocarcinoma, Stage 0 Uterine Corpus Cancer AJCC v6, Uterine Corpus Carcinosarcoma, Uterine Corpus Sarcoma, Malignant Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm, and Malignant Endometrial Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.