Overview

NCI Definition: A malignant neoplasm that affects the uterine corpus. Representative examples include endometrial carcinoma, carcinosarcoma, leiomyosarcoma, and adenosarcoma. [1]

Malignant uterine corpus neoplasms most frequently harbor alterations in TP53, PIK3CA, PTEN, ARID1A, and PIK3R1 [2].

Most Commonly Altered Genes in Malignant Uterine Corpus Neoplasm

TP53 Mutation, PIK3CA Mutation, PTEN Mutation, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in malignant uterine corpus neoplasm [2].

Top Alterations in Malignant Uterine Corpus Neoplasm

Disease Details

Synonyms
Malignant Corpus Uteri Tumor, Malignant Neoplasm of Uterine Body, Malignant Uterine Body Tumor, Malignant Tumor of the Uterine Body, Malignant Corpus Uteri Neoplasm, Malignant Uterine Body Neoplasm, Malignant Uterine Corpus Tumor, Malignant Neoplasm of the Uterine Body, Malignant Tumor of Uterine Body
Parent(s)
Malignant Uterine Neoplasm
Children
Stage 0 Uterine Corpus Cancer AJCC v6, Uterine Corpus Sarcoma, Uterine Corpus PEComa, Uterine Corpus Carcinosarcoma, Uterine Corpus Choriocarcinoma, Malignant Endometrial Neoplasm, and Malignant Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.