Overview

Malignant uterine neoplasms most frequently harbor alterations in TP53, PIK3CA, PTEN, ARID1A, and PIK3R1 [2].

Most Commonly Altered Genes in Malignant Uterine Neoplasm

PIK3CA Mutation, TP53 Mutation, PTEN Mutation, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in malignant uterine neoplasm [2].

Top Alterations in Malignant Uterine Neoplasm

Significant Genes in Malignant Uterine Neoplasm

AKT1 +

ALK +

ATM +

ATR +

BRAF +

BRCA1 +

BRCA2 +

CCND1 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK2 +

CSF1R +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

EXO1 +

FANCA +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

KDR +

KIT +

MET +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

NBN +

NRG1 +

NTRK1 +

NTRK2 +

NTRK3 +

PALB2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

RAD51C +

RAF1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

SSBP1 +

TSC1 +

TSC2 +

VHL +

Disease Details

Synonyms
Uterine Cancer
Parent(s)
Uterine Neoplasm
Children
Malignant Cervical Neoplasm, Malignant Uterine Corpus Neoplasm, Uterine Sarcoma, and Uterine Carcinosarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.