Associated Genetic Biomarkers

Overview

NCI Definition: A primary or metastatic malignant neoplasm involving the vagina. Representative examples include carcinomas and sarcomas. [1]

Malignant vaginal neoplasms most frequently harbor alterations in TP53, KRAS, RASA1, KMT2D, and JAK2 [2].

Most Commonly Altered Genes in Malignant Vaginal Neoplasm

TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in malignant vaginal neoplasm [2].

Top Alterations in Malignant Vaginal Neoplasm

Significant Genes in Malignant Vaginal Neoplasm

ERBB2 +

Disease Details

Synonyms
Malignant Neoplasm of Vagina, Malignant Tumor of the Vagina, Malignant Neoplasm of the Vagina, Malignant Tumor of Vagina, Malignant Vagina Neoplasm, Malignant Vaginal Tumor, Malignant Vagina Tumor, Vaginal Cancer
Parent(s)
Malignant Vulvar/Vaginal Neoplasm
Children
Vaginal Yolk Sac Tumor, Malignant Vaginal Mixed Epithelial and Mesenchymal Neoplasm, Malignant Vaginal Glandular Neoplasm, Vaginal Carcinoma, Vaginal Melanoma, and Vaginal Sarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.