NCI Definition: A neoplasm that arises from mature B-lymphocytes or plasma cells. Representative examples include mature B-cell non-Hodgkin lymphomas, chronic lymphocytic leukemia, hairy cell leukemia, and plasma cell neoplasms. [1]

Mature B-cell neoplasms most frequently harbor alterations in KMT2D, CREBBP, TP53, BCL2, and MYD88 [2].

Most Commonly Altered Genes in Mature B-Cell Neoplasm

KMT2D Mutation, CREBBP Mutation, TP53 Mutation, BCL2 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in mature B-cell neoplasm [2].

Top Alterations in Mature B-Cell Neoplasm

Disease Details

Mature B-Cell Lymphocytic Neoplasm
B-Cell Neoplasm
B-Cell Proliferation of Uncertain Malignant Potential, Splenic B-Cell Lymphoma/Leukemia, Unclassifiable, B-Cell Prolymphocytic Leukemia, Plasma Cell Neoplasm, Hairy Cell Leukemia, Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Small Lymphocytic Leukemia, Mature B-Cell Non-Hodgkin Lymphoma, and Monoclonal B-Cell Lymphocytosis
OncoTree Name
Mature B-Cell Neoplasms
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.