Mature B-cell non-hodgkin lymphomas most frequently harbor alterations in KMT2D, CREBBP, BCL2, TP53, and TNFRSF14 [2].

Most Commonly Altered Genes in Mature B-Cell Non-Hodgkin Lymphoma

CREBBP Mutation, KMT2D Mutation, BCL2 Mutation, KMT2fs, and TP53 Mutation are the most common alterations in mature B-cell non-hodgkin lymphoma [2].

Top Alterations in Mature B-Cell Non-Hodgkin Lymphoma

Significant Genes in Mature B-Cell Non-Hodgkin Lymphoma


BCL2 +

BCL6 +



Disease Details

Mature B-Cell Neoplasm
Primary Cutaneous B-Cell Non-Hodgkin Lymphoma, Heavy Chain Disease, Mantle Cell Lymphoma, Burkitt-Like Lymphoma with 11q Aberration, Small Lymphocytic Lymphoma, Lymphoplasmacytic Lymphoma, Mature B-Cell Lymphoma/Leukemia, Diffuse Large B-Cell Lymphoma, Large B-Cell Lymphoma with IRF4 Rearrangement, Splenic Diffuse Red Pulp Small B-Cell Lymphoma, Follicular Lymphoma, Composite Lymphoma, Burkitt Lymphoma, and Marginal Zone Lymphoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.