Mature B-cell non-hodgkin lymphomas most frequently harbor alterations in KMT2D, CREBBP, BCL2, TP53, and MYD88 [2].

Most Commonly Altered Genes in Mature B-Cell Non-Hodgkin Lymphoma

KMT2D Mutation, CREBBP Mutation, BCL2 Mutation, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in mature B-cell non-hodgkin lymphoma [2].

Top Alterations in Mature B-Cell Non-Hodgkin Lymphoma

Significant Genes in Mature B-Cell Non-Hodgkin Lymphoma


BCL2 +


Disease Details

Mature B-Cell Neoplasm
Heavy Chain Disease, Marginal Zone Lymphoma, Burkitt-Like Lymphoma with 11q Aberration, Small Lymphocytic Lymphoma, Diffuse Large B-Cell Lymphoma, Burkitt Lymphoma, Large B-Cell Lymphoma with IRF4 Rearrangement, Follicular Lymphoma, Lymphoplasmacytic Lymphoma, Mantle Cell Lymphoma, Splenic Diffuse Red Pulp Small B-Cell Lymphoma, Composite Lymphoma, and Mature B-Cell Lymphoma/Leukemia


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.