Overview

NCI Definition: A group of neoplasms composed of T-lymphocytes with a mature (peripheral/post-thymic) immunophenotypic profile and/or NK-cells. [1]

Significant Genes in Mature T-Cell and NK-Cell Neoplasm

ABL1 +

AFF1 +

ASXL1 +

BCR +

DEK +

ELL +

FLT3 +

IKZF1 +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NPM1 +

NUP214 +

PBX1 +

RPN1 +

RUNX1 +

TCF3 +

TP53 +

Disease Details

Synonyms
Mature T-Cell Neoplasm, Mature T Cell and NK Cell Neoplasm, Mature T and NK Cell Neoplasm, Mature T Cell Neoplasm
Parent(s)
T-Cell and NK-Cell Neoplasm
Children
Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma, Aggressive NK-Cell Leukemia, Chronic Lymphoproliferative Disorder of NK-Cells, Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder, Primary Cutaneous CD4-Positive Small/Medium T-Cell Lymphoproliferative Disorder, T-Cell Proliferation of Uncertain Malignant Potential, T-Cell Prolymphocytic Leukemia, Hydroa Vacciniforme-Like Lymphoproliferative Disorder, and T-Cell Large Granular Lymphocyte Leukemia
OncoTree Name
Mature T and NK Neoplasms
OncoTree Code
MTNN

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.