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Mediastinal Lymphoma

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Associated Genetic Biomarkers

Overview

NCI Definition: A lymphoma that arises from the mediastinum. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma. [1]

Mediastinal lymphomas most frequently harbor alterations in SOCS1, TNFAIP3, XPO1, CIITA, and STAT6 [2].

Most Commonly Altered Genes in Mediastinal Lymphoma

SOCS1fs, XPO1 Mutation, XPO1 E571K, TNFAIP3fs, and STAT6 Mutation are the most common alterations in mediastinal lymphoma [2].

Top Alterations in Mediastinal Lymphoma

Clinical Trials

View Clinical Trials for Mediastinal Lymphoma

Disease Details

Synonyms
Lymphoma of the Mediastinum, Lymphoma of Mediastinum, Primary Mediastinal Lymphoma, Mediastinal Malignant Lymphoma
Parent(s)
Malignant Mediastinal Neoplasm
Children
Mediastinal T Lymphoblastic Lymphoma, Mediastinal Hodgkin Lymphoma, Primary Mediastinal B-Cell Lymphoma, and Thymic Lymphoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.