Diseases /
Mediastinal Lymphoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A lymphoma that arises from the mediastinum. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma. [1]
Mediastinal lymphomas most frequently harbor alterations in SOCS1, TNFAIP3, XPO1, CIITA, and STAT6 [2].
SOCS1fs, XPO1 Mutation, XPO1 E571K, TNFAIP3fs, and STAT6 Mutation are the most common alterations in mediastinal lymphoma [2].
Clinical Trials
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.