Associated Genetic Biomarkers
NCI Definition: A lymphoma that arises from the mediastinum. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma. 
Mediastinal lymphomas most frequently harbor alterations in SOCS1, TNFAIP3, XPO1, CIITA, and STAT6 .
SOCS1fs, XPO1 Mutation, XPO1 E571K, TNFAIP3fs, and STAT6 Mutation are the most common alterations in mediastinal lymphoma .
There is 1 clinical trial for mediastinal lymphoma, of which 1 is open and 0 are completed or closed. Of the trial that contains mediastinal lymphoma as an inclusion criterion, 1 is phase 1 (1 open).
CD19 is the most frequent gene inclusion criterion for mediastinal lymphoma clinical trials .
Blinatumomab and lenalidomide are the most common interventions in mediastinal lymphoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.