Associated Genetic Biomarkers

Overview

NCI Definition: A lymphoma that arises from the mediastinum. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma. [1]

Mediastinal lymphomas most frequently harbor alterations in SOCS1, TNFAIP3, XPO1, CIITA, and STAT6 [2].

Most Commonly Altered Genes in Mediastinal Lymphoma

SOCS1fs, XPO1 Mutation, XPO1 E571K, TNFAIP3fs, and STAT6 Mutation are the most common alterations in mediastinal lymphoma [2].

Top Alterations in Mediastinal Lymphoma

Disease Details

Synonyms
Lymphoma of Mediastinum, Mediastinal Malignant Lymphoma, Lymphoma of the Mediastinum, Primary Mediastinal Lymphoma
Parent(s)
Malignant Mediastinal Neoplasm
Children
Primary Mediastinal B-Cell Lymphoma, Thymic Lymphoma, Mediastinal Hodgkin Lymphoma, and Mediastinal T Lymphoblastic Lymphoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.