Overview

NCI Definition: An infiltrating breast carcinoma with a relatively favorable prognosis. It is an uncommon carcinoma, accounting for less than 1% of all infiltrating breast carcinomas. It is well circumscribed, with soft cut surface and often of considerable size. Microscopically, the predominant growth pattern is syncytial with broad anastomosing bands or sheets of malignant cells. The malignant cells are round with abundant cytoplasm and vesicular nuclei. The sheets of malignant cells are associated with a marked lymphoplasmacytic infiltrate. Glandular or tubular structures are absent. [1]

Significant Genes in Medullary Breast Carcinoma

ERBB2 +

Disease Details

Synonyms
Infiltrating Medullary Carcinoma of Breast, Invasive Medullary Breast Carcinoma, Medullary Breast Carcinoma with Lymphoid Stroma, Invasive Medullary Carcinoma of the Breast, Infiltrating Medullary Carcinoma of the Breast, Invasive Medullary Carcinoma of Breast, Medullary Carcinoma of Breast, Medullary Carcinoma of the Breast
Parent(s)
Breast Invasive Ductal Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.