Overview

NCI Definition: A medulloblastoma characterized by nodularity and neuronal differentiation. [1]

Significant Genes in Medulloblastoma with Extensive Nodularity

APC +

CDK6 +

CTDNEP1 +

CTNNB1 +

DDX3X +

GLI2 +

KDM6A +

KMT2C +

KMT2D +

LRP1B +

MDM4 +

MYC +

MYCL +

MYCN +

OTX2 +

PPM1D +

PTCH1 +

PTEN +

PVT1 +

SHH +

SMARCA4 +

SMO +

SNCAIP +

SUFU +

TERT +

TP53 +

YAP1 +

ZMYM3 +

Disease Details

Synonyms
Nodular Medulloblastoma, Cerebellar Neuroblastoma, Medulloblastoma with Extensive Nodularity and Advanced Neuronal Differentiation
Parent(s)
Medulloblastoma
OncoTree Name
Medulloblastoma with Extensive Nodularity
OncoTree Code
MBEN

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.