Overview

NCI Definition: A generally slow growing tumor attached to the dura mater. It is composed of neoplastic meningothelial (arachnoidal) cells. It typically occurs in adults, often women and it has a wide range of histopathological appearances. Of the various subtypes, meningothelial, fibrous and transitional meningiomas are the most common. Most meningiomas are WHO grade I tumors, and some are WHO grade II or III tumors. Most subtypes share a common clinical behavior, although some subtypes are more likely to recur and follow a more aggressive clinical course. (Adapted from WHO) [1]

Meningiomas most frequently harbor alterations in NF2, TRAF7, CDKN2A, SMO, and KMT2D [2].

Most Commonly Altered Genes in Meningioma

NF2 Mutation, NF2fs, NF2 Nonsense, SMO Mutation, and CDKN2A Loss are the most common alterations in meningioma [2].

Top Alterations in Meningioma

Significant Genes in Meningioma

CCND1 +

CCND2 +

CDK4 +

CDK6 +

CDKN2A +

CDKN2B +

CDKN2C +

EGFR +

IDH1 +

IDH2 +

MYCN +

NF2 +

SMO +

Disease Details

Synonyms
Meningioma, NOS, MENINGIOMA, UNDETERMINED
Parent(s)
Meningeal Neoplasm
Children
Jugular Foramen Meningioma, Intracranial Meningioma, Grade III Meningioma, Parapharyngeal Meningioma, Grade II Meningioma, Periocular Meningioma, Hereditary Meningioma, Grade I Meningioma, Childhood Meningioma, and Spinal Canal And Spinal Cord Meningioma
OncoTree Name
Meningioma
OncoTree Code
MNG

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.