Overview

NCI Definition: A generally slow growing tumor attached to the dura mater. It is composed of neoplastic meningothelial (arachnoidal) cells. It typically occurs in adults, often women and it has a wide range of histopathological appearances. Of the various subtypes, meningothelial, fibrous and transitional meningiomas are the most common. Most meningiomas are WHO grade I tumors, and some are WHO grade II or III tumors. Most subtypes share a common clinical behavior, although some subtypes are more likely to recur and follow a more aggressive clinical course. (Adapted from WHO) [1]

Meningiomas most frequently harbor alterations in NF2, TRAF7, CDKN2A, SMO, and KMT2D [2].

Most Commonly Altered Genes in Meningioma

NF2 Mutation, NF2fs, NF2 Nonsense, SMO Mutation, and CDKN2A Loss are the most common alterations in meningioma [2].

Top Alterations in Meningioma

Significant Genes in Meningioma

CCND1 +

CCND2 +

CDK4 +

CDK6 +

CDKN2A +

CDKN2B +

CDKN2C +

EGFR +

IDH1 +

IDH2 +

MYCN +

NF2 +

SMO +

Disease Details

Synonyms
Meningioma, NOS, MENINGIOMA, UNDETERMINED
Parent(s)
Meningeal Neoplasm
Children
Grade I Meningioma, Jugular Foramen Meningioma, Hereditary Meningioma, Parapharyngeal Meningioma, Intracranial Meningioma, Grade II Meningioma, Periocular Meningioma, Childhood Meningioma, Spinal Canal And Spinal Cord Meningioma, and Grade III Meningioma
OncoTree Name
Meningioma
OncoTree Code
MNG

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.