Overview

NCI Definition: A generally slow growing tumor attached to the dura mater. It is composed of neoplastic meningothelial (arachnoidal) cells. It typically occurs in adults, often women and it has a wide range of histopathological appearances. Of the various subtypes, meningothelial, fibrous and transitional meningiomas are the most common. Most meningiomas are WHO grade I tumors, and some are WHO grade II or III tumors. Most subtypes share a common clinical behavior, although some subtypes are more likely to recur and follow a more aggressive clinical course. (Adapted from WHO) [1]

Significant Genes in Meningioma

CCND1 +

CCND2 +

CDK4 +

CDK6 +

CDKN2A +

CDKN2B +

CDKN2C +

EGFR +

IDH1 +

IDH2 +

MYCN +

NF2 +

SMO +

Disease Details

Synonyms
Meningioma, NOS, MENINGIOMA, UNDETERMINED
Parent(s)
Meningeal Neoplasm
Children
Childhood Meningioma, Spinal Canal And Spinal Cord Meningioma, Hereditary Meningioma, Periocular Meningioma, Grade III Meningioma, Parapharyngeal Meningioma, Jugular Foramen Meningioma, Intracranial Meningioma, Grade I Meningioma, and Grade II Meningioma
OncoTree Name
Meningioma
OncoTree Code
MNG

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.