Overview

NCI Definition: A usually malignant and aggressive neoplasm of the mesothelium which is often associated with exposure to asbestos. [1]

Mesotheliomas most frequently harbor alterations in BAP1, CDKN2A, NF2, CDKN2B, and TP53 [2].

Most Commonly Altered Genes in Mesothelioma

BAP1 Mutation, CDKN2A Loss, CDKN2B Loss, NF2 Mutation, and SETD2 Mutation are the most common alterations in mesothelioma [2].

Top Alterations in Mesothelioma

Significant Genes in Mesothelioma

ALK +

ARID1A +

ATM +

ATR +

ATRX +

BAP1 +

BARD1 +

BLM +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CDK12 +

CDK2 +

CDK4 +

CHEK1 +

CHEK2 +

EGFR +

ERBB2 +

ERCC1 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

FAM175A +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FEN1 +

HDAC1 +

HDAC2 +

IDH1 +

IDH2 +

KRAS +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MUTYH +

NBN +

NPM1 +

NTRK1 +

PALB2 +

PARP1 +

PARP2 +

PMS1 +

PMS2 +

POLD1 +

POLE +

PPP2R1A +

PPP2R2A +

PRKDC +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD52 +

RAD54L +

RET +

ROS1 +

RPA1 +

SLX4 +

SMARCB1 +

STAG2 +

STK11 +

WRN +

XRCC1 +

Disease Details

Synonyms
MESOTHELIOMA, UNDETERMINED
Parent(s)
Mesothelial Neoplasm
Children
Pleural Mesothelioma, Peritoneal Mesothelioma, Benign Mesothelioma, Testicular Mesothelioma, Pericardial Mesothelioma, and Malignant Mesothelioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.