Overview

NCI Definition: A usually malignant and aggressive neoplasm of the mesothelium which is often associated with exposure to asbestos. [1]

Mesotheliomas most frequently harbor alterations in BAP1, NF2, TP53, CDKN2A, and CDKN2B [2].

Most Commonly Altered Genes in Mesothelioma

BAP1 Mutation, TP53 Mutation, CDKN2B Loss, CDKN2A Loss, and NF2 Mutation are the most common alterations in mesothelioma [2].

Top Alterations in Mesothelioma

Significant Genes in Mesothelioma

ARID1A +

ATM +

ATR +

ATRX +

BAP1 +

BARD1 +

BLM +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CDK12 +

CDK2 +

CDK4 +

CHEK1 +

CHEK2 +

ERBB2 +

ERCC1 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

FAM175A +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FEN1 +

HDAC1 +

HDAC2 +

IDH1 +

IDH2 +

MDM2 +

MDM4 +

MLF1 +

MLH1 +

MRE11A +

MSH2 +

MSH6 +

MUTYH +

NBN +

NPM1 +

PALB2 +

PARP1 +

PARP2 +

PMS2 +

POLD1 +

PPP2R1A +

PPP2R2A +

PRKDC +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD52 +

RAD54L +

RPA1 +

SLX4 +

STAG2 +

STK11 +

WRN +

XRCC1 +

Disease Details

Synonyms
MESOTHELIOMA, UNDETERMINED
Parent(s)
Mesothelial Neoplasm
Children
Benign Mesothelioma, Pleural Mesothelioma, Peritoneal Mesothelioma, Testicular Mesothelioma, Pericardial Mesothelioma, and Malignant Mesothelioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.