Overview

NCI Definition: A group of invasive breast carcinomas characterized by the presence of an adenocarcinomatous component which is admixed with a dominant component that is composed of squamous cells, spindle cells, or mesenchymal cells. [1]

Metaplastic breast carcinomas most frequently harbor alterations in TP53, PIK3CA, MYC, RECQL4, and PTEN [2].

Most Commonly Altered Genes in Metaplastic Breast Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PIK3CA Mutation, and PIK3CA H1047R are the most common alterations in metaplastic breast carcinoma [2].

Top Alterations in Metaplastic Breast Carcinoma

Disease Details

Synonyms
Metaplastic Carcinoma of the Breast, Breast metaplastic carcinoma, Metaplastic Carcinoma of Breast
Parent(s)
Invasive Breast Carcinoma
Children
Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma and Epithelial Type Metaplastic Breast Cancer
OncoTree Name
Metaplastic Breast Cancer
OncoTree Code
MBC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.