Overview

NCI Definition: A group of invasive breast carcinomas characterized by the presence of an adenocarcinomatous component which is admixed with a dominant component that is composed of squamous cells, spindle cells, or mesenchymal cells. [1]

Metaplastic breast carcinomas most frequently harbor alterations in TP53, PIK3CA, MYC, RECQL4, and HRAS [2].

Most Commonly Altered Genes in Metaplastic Breast Carcinoma

TP53 Mutation, PIK3CA Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and PIK3CA H1047R are the most common alterations in metaplastic breast carcinoma [2].

Top Alterations in Metaplastic Breast Carcinoma

Disease Details

Synonyms
Metaplastic Carcinoma of Breast, Metaplastic Carcinoma of the Breast
Parent(s)
Invasive Breast Carcinoma
Children
Epithelial Type Metaplastic Breast Cancer and Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma
OncoTree Name
Metaplastic Breast Cancer
OncoTree Code
MBC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.