Overview

NCI Definition: A tumor composed of two or more glial cell types (astrocytes, ependymal cells, and oligodendrocytes). [1]

Mixed gliomas most frequently harbor alterations in IDH1, TP53, ATRX, TERT, and NOTCH1 [2].

Most Commonly Altered Genes in Mixed Glioma

IDH1 Mutation, IDH1 Codon 132 Missense, IDH1 R132H, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in mixed glioma [2].

Top Alterations in Mixed Glioma

Significant Genes in Mixed Glioma

IDH1 +

IDH2 +

Disease Details

Synonyms
Mixed Glial Neoplasm, GLIOMA, MIXED, MALIGNANT, Mixed Neuroglial Neoplasm, Glioma, Mixed, Mixed Neuroglial Tumor, Mixed Glial Tumor
Parent(s)
Diffuse Glioma
Children
Mixed Astrocytoma-Ependymoma-Oligodendroglioma, Mixed Astrocytoma-Ependymoma, Oligoastrocytoma, and Anaplastic Oligoastrocytoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.