NCI Definition: A breast carcinoma characterized by the presence of a lobular and a ductal component. The ductal component comprises less than 50 percent of the tumor. [1]

Mixed lobular and ductal breast carcinomas most frequently harbor alterations in PIK3CA, TP53, CDH1, USH2A, and RYR2 [2].

Most Commonly Altered Genes in Mixed Lobular and Ductal Breast Carcinoma

PIK3CA Mutation, PIK3CA Codon 1047 Missense, PIK3CA H1047R, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in mixed lobular and ductal breast carcinoma [2].

Top Alterations in Mixed Lobular and Ductal Breast Carcinoma

Significant Genes in Mixed Lobular and Ductal Breast Carcinoma

CDH1 +

Disease Details

Malignant Mixed Neoplasm
OncoTree Name
Breast Mixed Ductal and Lobular Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.