Overview

NCI Definition: An acute leukemia of ambiguous lineage. It is characterized by the presence of either separate populations of blasts of more than one lineage, or one population of blasts co-expressing markers of more than one lineage. [1]

Mixed phenotype acute leukemias most frequently harbor alterations in RUNX1, DNMT3A, TP53, TET2, and JAK3 [2].

Most Commonly Altered Genes in Mixed Phenotype Acute Leukemia

RUNX1 Mutation, TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and TET2 Mutation are the most common alterations in mixed phenotype acute leukemia [2].

Top Alterations in Mixed Phenotype Acute Leukemia

Significant Genes in Mixed Phenotype Acute Leukemia

ABL1 +

ABL2 +

AFF1 +

ASXL1 +

BCR +

CEP72 +

CRLF2 +

CSF1R +

DEK +

ELL +

EPOR +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT3 +

IL7R +

JAK1 +

JAK2 +

JAK3 +

KMT2A +

LYN +

MDM2 +

MDM4 +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NPM1 +

NRIP3 +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

PDGFRA +

PDGFRB +

PPM1D +

RPN1 +

RUNX1 +

SH2B3 +

SMARCA4 +

SMARCB1 +

TET2 +

TP53 +

TYK2 +

Disease Details

Parent(s)
Acute Leukemia of Ambiguous Lineage
Children
Mixed Phenotype Acute Leukemia, B/Myeloid, NOS, Mixed Phenotype Acute Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, Acute Bilineal Leukemia, Mixed Phenotype Acute Leukemia with t(v;11q23.3); KMT2A Rearranged, Acute Biphenotypic Leukemia, and Mixed Phenotype Acute Leukemia, T/Myeloid, NOS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.