Overview

NCI Definition: An acute leukemia of ambiguous lineage. It is characterized by the presence of either separate populations of blasts of more than one lineage, or one population of blasts co-expressing markers of more than one lineage. [1]

Significant Genes in Mixed Phenotype Acute Leukemia

ABL1 +

AFF1 +

BCR +

CBFA2T3 +

CREBBP +

DEK +

ELL +

ERG +

FLT3 +

FUS +

KAT6A +

KMT2A +

MDM2 +

MDM4 +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NUP214 +

PBX1 +

RPN1 +

RUNX1 +

TCF3 +

TET2 +

TP53 +

Disease Details

Parent(s)
Acute Leukemia of Ambiguous Lineage
Children
Mixed Phenotype Acute Leukemia, B/Myeloid, NOS, Mixed Phenotype Acute Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, Mixed Phenotype Acute Leukemia with t(v;11q23.3); KMT2A Rearranged, Acute Bilineal Leukemia, Acute Biphenotypic Leukemia, and Mixed Phenotype Acute Leukemia, T/Myeloid, NOS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.