Diseases /
Mixed Phenotype Acute Leukemia
Back to Diseases List
Associated Genetic Biomarkers
Overview
NCI Definition: An acute leukemia of ambiguous lineage. It is characterized by the presence of either separate populations of blasts of more than one lineage, or one population of blasts co-expressing markers of more than one lineage. [1]
Mixed phenotype acute leukemias most frequently harbor alterations in RUNX1, DNMT3A, TP53, TET2, and JAK3 [2].
RUNX1 Mutation, TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and TET2 Mutation are the most common alterations in mixed phenotype acute leukemia [2].
Clinical Trials
Significant Genes in Mixed Phenotype Acute Leukemia
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.