Overview

NCI Definition: A plasma cell disorder in which an abnormal amount of a single immunoglobulin is present in the serum. Up to 25% of cases of monoclonal gammopathy of undetermined significance (MGUS) progress to a B-cell malignancy or myeloma. MGUS may occur in conjunction with various carcinomas, chronic inflammatory and infectious conditions, and other diseases. [1]

Monoclonal gammopathy of undetermined significances most frequently harbor alterations in TP53, CIC, NOTCH4, MYD88, and EP300 [2].

Most Commonly Altered Genes in Monoclonal Gammopathy of Undetermined Significance

TP53 Nonsense, TP53 Mutation, TP53 Exon 7 Mutation, TP53 D228*, and TP53 c.217-c.1178 Missense are the most common alterations in monoclonal gammopathy of undetermined significance [2].

Top Alterations in Monoclonal Gammopathy of Undetermined Significance

Disease Details

Synonyms
MGUS, Monoclonal Gammopathy of Undetermined Significance (MGUS), monoclonal gammopathy of undetermined significance, Monoclonal gammopathy of undetermined significance (MGUS)
Parent(s)
B-Cell Proliferation of Uncertain Malignant Potential
Children
IgM Monoclonal Gammopathy of Undetermined Significance and Non-IgM Monoclonal Gammopathy of Undetermined Significance
OncoTree Name
Monoclonal Gammopathy of Undetermined Significance
OncoTree Code
MGUS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.