Monoclonal Gammopathy of Undetermined Significance
NCI Definition: A plasma cell disorder in which an abnormal amount of a single immunoglobulin is present in the serum. Up to 25% of cases of monoclonal gammopathy of undetermined significance (MGUS) progress to a B-cell malignancy or myeloma. MGUS may occur in conjunction with various carcinomas, chronic inflammatory and infectious conditions, and other diseases. 
Monoclonal gammopathy of undetermined significances most frequently harbor alterations in TP53, CIC, NOTCH4, MYD88, and EP300 .
TP53 Nonsense, TP53 Mutation, TP53 Exon 7 Mutation, TP53 D228*, and TP53 c.217-c.1178 Missense are the most common alterations in monoclonal gammopathy of undetermined significance .
There is 1 clinical trial for monoclonal gammopathy of undetermined significance, of which 1 is open and 0 are completed or closed. Of the trial that contains monoclonal gammopathy of undetermined significance as an inclusion criterion, 1 is no phase specified (1 open).
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.