Overview

NCI Definition: A plasma cell disorder in which an abnormal amount of a single immunoglobulin is present in the serum. Up to 25% of cases of monoclonal gammopathy of undetermined significance (MGUS) progress to a B-cell malignancy or myeloma. MGUS may occur in conjunction with various carcinomas, chronic inflammatory and infectious conditions, and other diseases. [1]

Monoclonal gammopathy of undetermined significances most frequently harbor alterations in TP53, CIC, NOTCH4, MYD88, and EP300 [2].

Most Commonly Altered Genes in Monoclonal Gammopathy of Undetermined Significance

TP53 Nonsense, TP53 Mutation, TP53 Exon 7 Mutation, TP53 D228*, and TP53 c.217-c.1178 Missense are the most common alterations in monoclonal gammopathy of undetermined significance [2].

Top Alterations in Monoclonal Gammopathy of Undetermined Significance

Disease Details

Synonyms
Monoclonal gammopathy of undetermined significance (MGUS), Monoclonal Gammopathy of Undetermined Significance (MGUS), MGUS, monoclonal gammopathy of undetermined significance
Parent(s)
B-Cell Proliferation of Uncertain Malignant Potential
Children
Non-IgM Monoclonal Gammopathy of Undetermined Significance and IgM Monoclonal Gammopathy of Undetermined Significance
OncoTree Name
Monoclonal Gammopathy of Undetermined Significance
OncoTree Code
MGUS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.