Overview

NCI Definition: A plasma cell disorder in which an abnormal amount of a single immunoglobulin is present in the serum. Up to 25% of cases of monoclonal gammopathy of undetermined significance (MGUS) progress to a B-cell malignancy or myeloma. MGUS may occur in conjunction with various carcinomas, chronic inflammatory and infectious conditions, and other diseases. [1]

Disease Details

Synonyms
Monoclonal Gammopathy of Undetermined Significance (MGUS), MGUS, monoclonal gammopathy of undetermined significance, Monoclonal gammopathy of undetermined significance (MGUS)
Parent(s)
B-Cell Proliferation of Uncertain Malignant Potential
Children
IgM Monoclonal Gammopathy of Undetermined Significance and Non-IgM Monoclonal Gammopathy of Undetermined Significance
OncoTree Name
Monoclonal Gammopathy of Undetermined Significance
OncoTree Code
MGUS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.