NCI Definition: An invasive adenocarcinoma composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation. It may arise from the large and small intestine, appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary gland. [1]

Mucinous adenocarcinomas most frequently harbor alterations in KRAS, TP53, GNAS, APC, and SMAD4 [2].

Most Commonly Altered Genes in Mucinous Adenocarcinoma

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, TP53 Mutation, and TP53 Missense are the most common alterations in mucinous adenocarcinoma [2].

Top Alterations in Mucinous Adenocarcinoma

Disease Details

Gelatinous Adenocarcinoma, Gelatinous Carcinoma, Mucous Adenocarcinoma, Mucous Carcinoma, Invasive adenocarcinoma with mucinous features, Colloid Carcinoma, Mucoid Adenocarcinoma, ADENOCARCINOMA, MUCINOUS, MALIGNANT, Mucinous Carcinoma, Mucoid Carcinoma, Colloid Adenocarcinoma
Ovarian Mucinous Adenocarcinoma, Acinar Prostate Mucinous Adenocarcinoma, Pancreatic Colloid Carcinoma, Invasive Lung Mucinous Adenocarcinoma, Ampulla of Vater Mucinous Adenocarcinoma, Appendix Mucinous Adenocarcinoma, Endometrial Mucinous Adenocarcinoma, Uterine Ligament Mucinous Adenocarcinoma, Pseudomyxoma Peritonei, Gallbladder Mucinous Adenocarcinoma, Anal Mucinous Adenocarcinoma, Mucinous Breast Carcinoma, Colorectal Mucinous Adenocarcinoma, Vulvar Adenocarcinoma, Intestinal-Type, Small Intestinal Mucinous Adenocarcinoma, Mucinous Adenocarcinoma of the Vulva/Vagina, Bladder Mucinous Adenocarcinoma, Extrahepatic Bile Duct Mucinous Adenocarcinoma, Cervical Mucinous Adenocarcinoma, and Fallopian Tube Mucinous Adenocarcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.