Overview

NCI Definition: An invasive adenocarcinoma composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation. It may arise from the large and small intestine, appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary gland. [1]

Mucinous adenocarcinomas most frequently harbor alterations in KRAS, TP53, GNAS, APC, and SMAD4 [2].

Most Commonly Altered Genes in Mucinous Adenocarcinoma

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, TP53 Mutation, and TP53 Missense are the most common alterations in mucinous adenocarcinoma [2].

Top Alterations in Mucinous Adenocarcinoma

Disease Details

Synonyms
ADENOCARCINOMA, MUCINOUS, MALIGNANT, Mucinous Carcinoma, Colloid Carcinoma, Mucous Adenocarcinoma, Invasive adenocarcinoma with mucinous features, Mucoid Carcinoma, Gelatinous Adenocarcinoma, Mucous Carcinoma, Gelatinous Carcinoma, Mucoid Adenocarcinoma, Colloid Adenocarcinoma
Parent(s)
Adenocarcinoma
Children
Fallopian Tube Mucinous Adenocarcinoma, Mucinous Breast Carcinoma, Small Intestinal Mucinous Adenocarcinoma, Pancreatic Colloid Carcinoma, Ovarian Mucinous Adenocarcinoma, Uterine Ligament Mucinous Adenocarcinoma, Ampulla of Vater Mucinous Adenocarcinoma, Extrahepatic Bile Duct Mucinous Adenocarcinoma, Colorectal Mucinous Adenocarcinoma, Bladder Mucinous Adenocarcinoma, Pseudomyxoma Peritonei, Appendix Mucinous Adenocarcinoma, Vulvar Adenocarcinoma, Intestinal-Type, Mucinous Adenocarcinoma of the Vulva/Vagina, Cervical Mucinous Adenocarcinoma, Gallbladder Mucinous Adenocarcinoma, Endometrial Mucinous Adenocarcinoma, Anal Mucinous Adenocarcinoma, Invasive Lung Mucinous Adenocarcinoma, and Acinar Prostate Mucinous Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.