Overview

NCI Definition: An invasive adenocarcinoma composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation. It may arise from the large and small intestine, appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary gland. [1]

Mucinous adenocarcinomas most frequently harbor alterations in KRAS, TP53, GNAS, APC, and SMAD4 [2].

Most Commonly Altered Genes in Mucinous Adenocarcinoma

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, TP53 Mutation, and TP53 Missense are the most common alterations in mucinous adenocarcinoma [2].

Top Alterations in Mucinous Adenocarcinoma

Disease Details

Synonyms
Gelatinous Adenocarcinoma, Mucous Carcinoma, Mucinous Carcinoma, Mucoid Adenocarcinoma, Gelatinous Carcinoma, ADENOCARCINOMA, MUCINOUS, MALIGNANT, Colloid Adenocarcinoma, Invasive adenocarcinoma with mucinous features, Colloid Carcinoma, Mucoid Carcinoma, Mucous Adenocarcinoma
Parent(s)
Adenocarcinoma
Children
Pancreatic Colloid Carcinoma, Acinar Prostate Mucinous Adenocarcinoma, Mucinous Breast Carcinoma, Anal Mucinous Adenocarcinoma, Gallbladder Mucinous Adenocarcinoma, Mucinous Adenocarcinoma of the Vulva/Vagina, Endometrial Mucinous Adenocarcinoma, Bladder Mucinous Adenocarcinoma, Invasive Lung Mucinous Adenocarcinoma, Ampulla of Vater Mucinous Adenocarcinoma, Appendix Mucinous Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Uterine Ligament Mucinous Adenocarcinoma, Cervical Mucinous Adenocarcinoma, Pseudomyxoma Peritonei, Vulvar Adenocarcinoma, Intestinal-Type, Ovarian Mucinous Adenocarcinoma, Extrahepatic Bile Duct Mucinous Adenocarcinoma, Colorectal Mucinous Adenocarcinoma, and Small Intestinal Mucinous Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.