Overview

NCI Definition: A low grade carcinoma of the kidney characterized by the presence of tubules which are separated by mucinous stroma. Often the tubular structures have a spindle cell appearance. Patients are usually asymptomatic and occasionally they may present with hematuria or flank pain. [1]

Mucinous tubular and spindle cell carcinoma of the kidneys most frequently harbor alterations in MEF2B, INSR, ERBB3, CD79B, and BAP1 [2].

MEF2B P330T, INSR D569N, ERBB3 N414K, ERBB3 Mutation, and CD79B R141* are the most common alterations in mucinous tubular and spindle cell carcinoma of the kidney [2].

Significant Genes in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney

Disease Details

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.