NCI Definition: A peripheral (mature) T-cell lymphoma presenting in the skin with patches/plaques. It is characterized by epidermal and dermal infiltration of small to medium-sized T-cells with cerebriform nuclei. Patients with limited disease generally have an excellent prognosis. In the more advanced stages, the prognosis is poor. (WHO, 2001) [1]

Mycosis fungoidess most frequently harbor alterations in KMT2D, FAT1, CDKN2A, TP53, and SOCS1 [2].

Most Commonly Altered Genes in Mycosis Fungoides

KMT2D Mutation, FAT1 Mutation, CDKN2A Loss, CDKN2B Loss, and TP53 Mutation are the most common alterations in mycosis fungoides [2].

Top Alterations in Mycosis Fungoides

Significant Genes in Mycosis Fungoides




CARD11 +

CD79A +

CD79B +



Disease Details

MF, mycosis fungoides, Cutaneous T-cell lymphoma/Mycosis fungoides, CTCL/ Mycosis fungoides
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
OncoTree Name
Mycosis Fungoides
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.