Overview

NCI Definition: A myelodysplastic syndrome defined by 5-9% blasts in the bone marrow, and <5% blasts in the blood. Approximately 25% of cases progress to an acute leukemia. (WHO) [1]

Significant Genes in Myelodysplastic Syndrome with Excess Blasts-1

ABL1 +

AFF1 +

BCR +

ELL +

FLT3 +

IKZF1 +

KIT +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NPM1 +

NRIP3 +

PBX1 +

RPN1 +

TCF3 +

Disease Details

Synonyms
MDS-EB-1, Refractory Anemia with Excess Blasts-1, MDS with Excess Blasts-1, RAEB-I, RAEB-1
Parent(s)
Refractory Anemia with Excess Blasts
OncoTree Name
MDS with Excess Blasts-1
OncoTree Code
MDSEB1

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.