Additional sex combs like transcriptional regulator 1 (official symbol ASXL1) is a gene that codes for a chromatin-binding protein. Normal ASXL1 plays a role in embryonic development (Gene 2014). ASXL1 mutations are observed primarily in myelodysplastic syndromes, but they are also observed in colorectal and endometrial cancers (COSMIC).
Suggested Citation: Strickland, S., A. Kim. 2015. ASXL1. My Cancer Genome https://www.mycancergenome.org/content/disease/myelodysplastic-syndromes/asxl1/?tab=0 (Updated December 4).
Last Updated: December 4, 2015