BCL6 corepressor (BCOR) is a gene that encodes a protein of the same name. BCOR is a member of the ankyrin repeat domain containing gene family. The corepressor expressed by BCOR binds to BCL6, a DNA-binding protein that acts as a transcription repressor for genes involved in regulation of B cells, a type of immune cell (Gene 2014a, 2014b; Genetics Home Reference 2014). In cancer, BCOR mutations have been observed in myelodysplastic syndromes, endometrial cancer, and other cancers.
Suggested Citation: Strickland, S., A. Kim. 2014. BCOR. My Cancer Genome https://www.mycancergenome.org/content/disease/myelodysplastic-syndromes/bcor/?tab=0 (Updated September 23).
Last Updated: September 23, 2014