Serine/arginine-rich splicing factor 2 (SRSF2) is a gene that codes for one of the several serine/arginine-rich splicing factors. SRSF2 is a member of the spliceosome and is involved in mRNA processing (Gene 2014). Spliceosome mutations are observed in MDS, chronic lymphocytic leukemia (CLL), AML, and chronic myelomonocytic leukemia (CMML), and these mutations can cause abnormal expression patterns of some genes involved in cancer pathogenesis (Chesnais et al. 2012).
Suggested Citation: Strickland, S., A. Kim. 2015. SRSF2. My Cancer Genome https://www.mycancergenome.org/content/disease/myelodysplastic-syndromes/srsf2/?tab=0 (Updated December 7).
Last Updated: December 7, 2015