Stromal antigen 2 (STAG2) is a gene that codes for a subunit of the cohesin complex, which is involved in many cellular processes, such as DNA double-strand break repair and chromatid segregation during mitosis (Nasmyth and Haering 2009). Mutations in STAG2 have been observed in MDS, AML, bladder cancer, and other cancers (Losada 2014; Walter et al. 2013). Inactivation of cohesin may be a cause of aneuploidy in cancer (Gene 2014; Losada 2014).
Suggested Citation: Strickland, S., A. Kim. 2015. STAG2. My Cancer Genome https://www.mycancergenome.org/content/disease/myelodysplastic-syndromes/stag2/?tab=0 (Updated December 4).
Last Updated: December 4, 2015