Tet methylcytosine dioxygenase 2 (TET2; also known as ten-eleven translocation 2) is a gene that codes for a protein involved in epigenetic regulation of myelopoeisis (Gene 2014; Solary et al. 2014). TET2 is a tumor suppressor, and so in cancer, loss of TET2 function, which can occur via TET2 mutation, TET2 deletion, or IDH1 or IDH2 mutation, can cause myeloid or lymphoid transformations (Solary et al. 2014). Mutations in TET2 have been found in MDS, AML, ALL, and other hematologic malignancies.
Suggested Citation: Strickland, S., A. Kim. 2015. TET2. My Cancer Genome https://www.mycancergenome.org/content/disease/myelodysplastic-syndromes/tet2/?tab=0 (Updated December 4).
Last Updated: December 4, 2015