U2 small nuclear RNA auxiliary factor 1 (U2AF1) is a gene that encodes for a member of the spliceosome. The protein coded by this gene is part of the U2 auxiliary factor, which plays an important role in RNA splicing (Gene 2014). Spliceosome mutations are observed in MDS, chronic lymphocytic leukemia (CLL), AML, and chronic myelomonocytic leukemia (CMML), and these mutations can cause abnormal expression patterns of some genes involved in cancer pathogenesis (Chesnais et al. 2012).
Suggested Citation: Strickland, S., A. Kim. 2015. U2AF1. My Cancer Genome https://www.mycancergenome.org/content/disease/myelodysplastic-syndromes/u2af1/?tab=0 (Updated December 7).
Last Updated: December 7, 2015