Overview

NCI Definition: A partial or complete replacement of the bone marrow stroma by fibrous tissue. It can be a primary bone marrow lesion as part of the chronic myeloproliferative disorders (chronic idiopathic myelofibrosis), a manifestation of acute myeloid leukemia (acute panmyelosis with myelofibrosis), or a secondary phenomenon due to bone marrow involvement by a metastatic tumor (e.g., metastatic breast carcinoma). --2003 [1]

Myelofibrosiss most frequently harbor alterations in JAK2, ASXL1, TET2, ETV6, and CALR [2].

Most Commonly Altered Genes in Myelofibrosis

JAK2 Mutation, JAK2 V617F, ASXL1 Mutation, ASXL1 Frameshift, and TET2 Mutation are the most common alterations in myelofibrosis [2].

Top Alterations in Myelofibrosis

Significant Genes in Myelofibrosis

ABL1 +

AFF1 +

ASXL1 +

BCR +

CALR +

CBFB +

DEK +

ELL +

EZH2 +

FGFR3 +

FLT3 +

IDH1 +

IDH2 +

IGH +

IKZF1 +

JAK2 +

KIT +

KMT2A +

MAF +

MAFB +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MPL +

MYH11 +

NPM1 +

NUP214 +

PBX1 +

RPN1 +

RUNX1 +

RUNX1T1 +

SRSF2 +

TCF3 +

TP53 +

Disease Details

Parent(s)
Bone Marrow Disorder
Children
Primary Myelofibrosis and Secondary Myelofibrosis
OncoTree Name
Myelofibrosis/Osteomyelofibrosis
OncoTree Code
MYF

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.