Myeloid Leukemia Associated with Down Syndrome
NCI Definition: Acute myeloid leukemia or myelodysplastic syndrome occurring in children with Down syndrome. The acute myeloid leukemia is usually an acute megakaryoblastic leukemia, and is associated with GATA1 gene mutation. 
There is 1 clinical trial for myeloid leukemia associated with down syndrome, of which 1 is open and 0 are completed or closed. Of the trial that contains myeloid leukemia associated with down syndrome as an inclusion criterion, 1 is phase 3 (1 open).
Cytarabine, etoposide, and mitoxantrone are the most common interventions in myeloid leukemia associated with down syndrome clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.