Associated Genetic Biomarkers

Overview

NCI Definition: Proliferation of myeloid cells originating from a primitive stem cell. [1]

Myeloid neoplasms most frequently harbor alterations in TET2, ASXL1, DNMT3A, TP53, and JAK2 [2].

Most Commonly Altered Genes in Myeloid Neoplasm

JAK2 Mutation, JAK2 V617F, JAK2 Exon 14 Mutation, DNMT3A Mutation, and TP53 Mutation are the most common alterations in myeloid neoplasm [2].

Top Alterations in Myeloid Neoplasm

Significant Genes in Myeloid Neoplasm

AKT1 +

AKT2 +

AKT3 +

CBL +

CRKL +

CSF3R +

EZH2 +

FBXW7 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT3 +

GATA1 +

GATA2 +

HRAS +

IDH1 +

IDH2 +

JAK2 +

KIT +

KMT2A +

KRAS +

MAP2K1 +

MPL +

MTOR +

MYD88 +

NOTCH1 +

NPM1 +

NRAS +

PDGFRA +

PHF6 +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PTEN +

RB1 +

RICTOR +

RPTOR +

RUNX1 +

SF3B1 +

SRSF2 +

STAG2 +

STAT3 +

TP53 +

TSC1 +

TSC2 +

U2AF1 +

WT1 +

ZRSR2 +

Disease Details

Synonyms
Myeloid Tumor, Myleloid Malignancy
Parent(s)
Hematopoietic and Lymphoid Cell Neoplasm
Children
Mast Cell Neoplasm, Megakaryocytic Neoplasm, Myeloproliferative Neoplasm, Blastic Plasmacytoid Dendritic Cell Neoplasm, Myelodysplastic Syndromes, Myeloid Sarcoma, Myeloid Proliferations Associated with Down Syndrome, Myelodysplastic/Myeloproliferative Neoplasm, Therapy-Related Myeloid Neoplasm, Myeloid Neoplasms with Germline Predisposition, and Myeloid Leukemia
OncoTree Name
Myeloid Neoplasm
OncoTree Code
MNM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.