Associated Genetic Biomarkers

Overview

NCI Definition: Proliferation of myeloid cells originating from a primitive stem cell. [1]

Myeloid neoplasms most frequently harbor alterations in ASXL1, ETV6, TET2, DNMT3A, and TP53 [2].

Most Commonly Altered Genes in Myeloid Neoplasm

ASXL1 Mutation, ETV6 Mutation, TET2 Mutation, ETV6 Frameshift, and ASXL1 Frameshift are the most common alterations in myeloid neoplasm [2].

Top Alterations in Myeloid Neoplasm

Significant Genes in Myeloid Neoplasm

AKT1 +

AKT2 +

AKT3 +

CBL +

CRKL +

CSF3R +

EGFR +

ERBB2 +

EZH2 +

FBXW7 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT3 +

GATA1 +

GATA2 +

HRAS +

IDH1 +

IDH2 +

IRS2 +

JAK2 +

KIT +

KMT2A +

KRAS +

MAP2K1 +

MET +

MPL +

MTOR +

MYD88 +

NOTCH1 +

NPM1 +

NRAS +

PDGFRA +

PHF6 +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PTEN +

RB1 +

RICTOR +

RNF43 +

RPTOR +

RUNX1 +

SF3B1 +

SRSF2 +

STAG2 +

STAT3 +

TP53 +

TSC1 +

TSC2 +

U2AF1 +

WT1 +

ZRSR2 +

Disease Details

Synonyms
Myeloid Tumor, Myleloid Malignancy
Parent(s)
Hematopoietic and Lymphoid Cell Neoplasm
Children
Mast Cell Neoplasm, Myeloid Leukemia, Blastic Plasmacytoid Dendritic Cell Neoplasm, Myeloid Sarcoma, Myeloid Neoplasms with Germline Predisposition, Myelodysplastic/Myeloproliferative Neoplasm, Myeloid Proliferations Associated with Down Syndrome, Therapy-Related Myeloid Neoplasm, Megakaryocytic Neoplasm, Myelodysplastic Syndromes, and Myeloproliferative Neoplasm
OncoTree Name
Myeloid Neoplasm
OncoTree Code
MNM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.