Associated Genetic Biomarkers

Overview

NCI Definition: Proliferation of myeloid cells originating from a primitive stem cell. [1]

Significant Genes in Myeloid Neoplasm

ABL1 +

AKT1 +

AKT2 +

AKT3 +

ASXL1 +

BCR +

CBL +

CRKL +

CSF3R +

DEK +

EZH2 +

FBXW7 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT3 +

GATA1 +

GATA2 +

HRAS +

IDH1 +

IDH2 +

JAK2 +

KIT +

KMT2A +

KRAS +

MAP2K1 +

MECOM +

MPL +

MTOR +

MYD88 +

NOTCH1 +

NPM1 +

NRAS +

NUP214 +

PDGFRA +

PHF6 +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PTEN +

RB1 +

RICTOR +

RPN1 +

RPTOR +

RUNX1 +

SF3B1 +

SRSF2 +

STAG2 +

STAT3 +

TP53 +

TSC1 +

TSC2 +

U2AF1 +

WT1 +

ZRSR2 +

Disease Details

Synonyms
Myeloid Tumor, Myleloid Malignancy
Parent(s)
Hematopoietic and Lymphoid Cell Neoplasm
Children
Myeloproliferative Neoplasm, Myeloid Neoplasms with Germline Predisposition, Myeloid Leukemia, Myeloid Proliferations Associated with Down Syndrome, Myelodysplastic Syndromes, Blastic Plasmacytoid Dendritic Cell Neoplasm, Myelodysplastic/Myeloproliferative Neoplasm, Myeloid Sarcoma, Therapy-Related Myeloid Neoplasm, Mast Cell Neoplasm, and Megakaryocytic Neoplasm
OncoTree Name
Myeloid Neoplasm
OncoTree Code
MNM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.