Associated Genetic Biomarkers

Overview

NCI Definition: A tumor mass composed of myeloblasts or immature myeloid cells. It occurs in extramedullary sites or the bone. (WHO, 2001) [1]

Myeloid sarcomas most frequently harbor alterations in UBR5, U2AF1, STAG2, SAMHD1, and RUNX1 [2].

Most Commonly Altered Genes in Myeloid Sarcoma

UBR5 Mutation, UBR5 L2185Q, U2AF1 Q157P, U2AF1 Mutation, and U2AF1 Exon 6 Mutation are the most common alterations in myeloid sarcoma [2].

Top Alterations in Myeloid Sarcoma

Significant Genes in Myeloid Sarcoma

ABL1 +

AFF1 +

BCR +

CBFA2T3 +

CREBBP +

DEK +

ELL +

ETV6 +

FLT3 +

GLIS2 +

HOXA9 +

KAT6A +

KDM5A +

KMT2A +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

NRIP3 +

NSD1 +

NUP214 +

NUP98 +

PBX1 +

RPN1 +

RUNX1 +

TCF3 +

TP53 +

WT1 +

Disease Details

Synonyms
SARCOMA, MYELOID, MALIGNANT, Chloroma, Extramedullary Myeloid Tumor
Parent(s)
Myeloid Neoplasm
Children
Granulocytic Sarcoma
OncoTree Name
Myeloid Sarcoma
OncoTree Code
MS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.