Myelomas most frequently harbor alterations in KRAS, TP53, NRAS, TET2, and DNMT3A [2].

Most Commonly Altered Genes in Myeloma

KRAS Mutation, TP53 Mutation, NRAS Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in myeloma [2].

Top Alterations in Myeloma

Significant Genes in Myeloma



Disease Details

Solid Neoplasm
Leukemoid Reaction and Multiple Myeloma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.