Associated Genetic Biomarkers

Overview

NCI Definition: A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008) [1]

Significant Genes in Myeloproliferative Neoplasm

ABL1 +

AFF1 +

ASXL1 +

BCR +

CBFB +

DEK +

ELL +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT3 +

IDH1 +

IDH2 +

IGH +

IKZF1 +

KIT +

KMT2A +

MAF +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYH11 +

NPM1 +

NRIP3 +

NUP214 +

PBX1 +

PML +

RARA +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TP53 +

Disease Details

Synonyms
Chronic Myeloproliferative Disease, MPD, Chronic Myeloproliferative Disorder, Myeloproliferative Tumor, CMPD, MPN, Chronic Myeloproliferative Neoplasm, Myeloproliferative Disease, Myeloproliferative Disorder
Parent(s)
Myeloid Neoplasm
Children
Chronic Myeloid Leukemia, Essential Thrombocythemia, Primary Myelofibrosis, Chronic Eosinophilic Leukemia, NOS, Myeloproliferative Neoplasm, Unclassifiable, Chronic Neutrophilic Leukemia, and Polycythemia Vera
OncoTree Name
Myeloproliferative Neoplasms
OncoTree Code
MPN

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.