Associated Genetic Biomarkers

Overview

NCI Definition: A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008) [1]

Myeloproliferative neoplasms most frequently harbor alterations in JAK2, TET2, ASXL1, CALR, and DNMT3A [2].

Most Commonly Altered Genes in Myeloproliferative Neoplasm

JAK2 Mutation, JAK2 V617F, JAK2 Exon 14 Mutation, CALR Mutation, and ASXL1fs are the most common alterations in myeloproliferative neoplasm [2].

Top Alterations in Myeloproliferative Neoplasm

Significant Genes in Myeloproliferative Neoplasm

ABL1 +

AFF1 +

ASXL1 +

BCR +

CBFB +

DEK +

ELL +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT3 +

IDH1 +

IDH2 +

IGH +

IKZF1 +

KIT +

KMT2A +

MAF +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYH11 +

NPM1 +

NRIP3 +

NUP214 +

PBX1 +

PML +

RARA +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TP53 +

Disease Details

Synonyms
Chronic Myeloproliferative Disease, Chronic Myeloproliferative Disorder, MPN, CMPD, Myeloproliferative Tumor, Myeloproliferative Disorder, Myeloproliferative Disease, MPD, Chronic Myeloproliferative Neoplasm
Parent(s)
Myeloid Neoplasm
Children
Polycythemia Vera, Essential Thrombocythemia, Myeloproliferative Neoplasm, Unclassifiable, Chronic Eosinophilic Leukemia, NOS, Chronic Myeloid Leukemia, Chronic Neutrophilic Leukemia, and Primary Myelofibrosis
OncoTree Name
Myeloproliferative Neoplasms
OncoTree Code
MPN

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.