NCI Definition: A malignant fibroblastic neoplasm arising from the soft tissue. It is characterized by the presence of spindle-shaped cells, cellular pleomorphism, thin-walled blood vessels, fibrous septa, and myxoid stroma. [1]

Myxofibrosarcomas most frequently harbor alterations in TP53, CDKN2A, CDKN2B, and ATRX [2].

Most Commonly Altered Genes in Myxofibrosarcoma

TP53 Mutation, CDKN2A Loss, CDKN2B Loss, and ATRX Mutation are the most common alterations in myxofibrosarcoma [2].

Top Alterations in Myxofibrosarcoma

Significant Genes in Myxofibrosarcoma



Disease Details

Soft tissue myxofibrosarcoma, Myxoid MFH, Myxoid Fibrous Histiocytoma, Myxoid Malignant Fibrous Histiocytoma
Soft Tissue Fibrosarcoma
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OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.