Associated Genetic Biomarkers
NCI Definition: A malignant fibroblastic neoplasm arising from the soft tissue. It is characterized by the presence of spindle-shaped cells, cellular pleomorphism, thin-walled blood vessels, fibrous septa, and myxoid stroma. 
Myxofibrosarcomas most frequently harbor alterations in TP53, CDKN2A, ATRX, CDKN2B, and NOTCH1 .
TP53 Mutation, CDKN2A Loss, CDKN2B Loss, ATRX Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in myxofibrosarcoma .
There are 2 clinical trials for myxofibrosarcoma, of which 2 are open and 0 are completed or closed. Of the trials that contain myxofibrosarcoma as an inclusion criterion, 1 is phase 1 (1 open) and 1 is phase 2 (1 open).
PIK3CA and PTEN are the most frequent gene inclusion criteria for myxofibrosarcoma clinical trials .
Doxorubicin and ribociclib are the most common interventions in myxofibrosarcoma clinical trials.
Significant Genes in Myxofibrosarcoma
PIK3CA is an inclusion eligibility criterion in 1 clinical trial for myxofibrosarcoma, of which 1 is open and 0 are closed. Of the trial that contains PIK3CA status and myxofibrosarcoma as inclusion criteria, 1 is phase 2 (1 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.