Overview

NCI Definition: A liposarcoma characterized by the presence of round non-lipogenic primitive mesenchymal cells and small signet ring lipoblasts within a myxoid stoma with a branching vascular pattern. This category includes hypercellular lesions with round cell morphology, formerly known as round cell liposarcoma. [1]

Myxoid liposarcomas most frequently harbor alterations in PIK3CA and PTEN [2].

Most Commonly Altered Genes in Myxoid Liposarcoma

PIK3CA Mutation and PTEN Mutation are the most common alterations in myxoid liposarcoma [2].

Top Alterations in Myxoid Liposarcoma

Significant Genes in Myxoid Liposarcoma

DDIT3 +

FUS +

PIK3CA +

PTEN +

Disease Details

Synonyms
Myxoid/Round Cell Liposarcoma
Parent(s)
Liposarcoma
Children
Ovarian Myxoid Liposarcoma
OncoTree Name
Myxoid/Round-Cell Liposarcoma
OncoTree Code
MRLS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.