Overview

NCI Definition: A carcinoma arising from the nasopharyngeal epithelium. It includes the following types: keratinizing squamous cell carcinoma, nonkeratinizing carcinoma (differentiated and undifferentiated), basaloid squamous cell carcinoma, and papillary adenocarcinoma. [1]

Nasopharyngeal carcinomas most frequently harbor alterations in CDKN2B, CDKN2A, KMT2D, TP53, and CYLD [2].

Most Commonly Altered Genes in Nasopharyngeal Carcinoma

CDKN2B Loss, CDKN2A Loss, TP53 Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in nasopharyngeal carcinoma [2].

Top Alterations in Nasopharyngeal Carcinoma

Significant Genes in Nasopharyngeal Carcinoma

ABL1 +

BRAF +

DDR2 +

EGFR +

EPHA2 +

ERBB2 +

ERBB4 +

FGF19 +

FGF4 +

FGFR1 +

FGFR2 +

FLT1 +

FLT4 +

FRK +

KDR +

KIT +

MAPK11 +

PDGFRA +

PDGFRB +

RAF1 +

RET +

TEK +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

Disease Details

Synonyms
Nasopharyngeal carcinoma, Carcinoma of the Nasopharynx, NPC, Nasopharyngeal Throat Cancer, Carcinoma of Nasopharynx, Cancer of the Nasopharynx, Nasopharyngeal Cancer, nasopharyngeal cancer, Cancer of Nasopharynx
Parent(s)
Malignant Nasopharyngeal Neoplasm
Children
Nasopharyngeal Squamous Cell Carcinoma, Nasopharyngeal Papillary Adenocarcinoma, and Nasopharyngeal Salivary Gland-Type Carcinoma
OncoTree Name
Nasopharyngeal Carcinoma
OncoTree Code
NPC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.