Overview

NCI Definition: A carcinoma arising from the nasopharyngeal epithelium. It includes the following types: keratinizing squamous cell carcinoma, nonkeratinizing carcinoma (differentiated and undifferentiated), basaloid squamous cell carcinoma, and papillary adenocarcinoma. [1]

Nasopharyngeal carcinomas most frequently harbor alterations in KMT2D, TP53, CDKN2B, CDKN2A, and PIK3CA [2].

Most Commonly Altered Genes in Nasopharyngeal Carcinoma

KMT2D Mutation, TP53 Mutation, CDKN2B Loss, CDKN2A Loss, and TP53 c.217-c.1178 Missense are the most common alterations in nasopharyngeal carcinoma [2].

Top Alterations in Nasopharyngeal Carcinoma

Significant Genes in Nasopharyngeal Carcinoma

ABL1 +

BRAF +

DDR2 +

EGFR +

EPHA2 +

ERBB2 +

ERBB4 +

FGF19 +

FGF4 +

FGFR1 +

FGFR2 +

FLT1 +

FLT4 +

FRK +

KDR +

KIT +

MAPK11 +

PDGFRA +

PDGFRB +

RAF1 +

RET +

TEK +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

Disease Details

Synonyms
Nasopharyngeal Throat Cancer, Cancer of the Nasopharynx, nasopharyngeal cancer, Carcinoma of the Nasopharynx, Cancer of Nasopharynx, Nasopharyngeal carcinoma, Carcinoma of Nasopharynx, Nasopharyngeal Cancer, NPC
Parent(s)
Malignant Nasopharyngeal Neoplasm
Children
Nasopharyngeal Squamous Cell Carcinoma
OncoTree Name
Nasopharyngeal Carcinoma
OncoTree Code
NPC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.