NCI Definition: A nonkeratinizing carcinoma which occurs predominantly in the nasopharynx but also in the tonsils and rarely in other anatomic sites. It is characterized by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, syncytial growth pattern, and a lymphoplasmacytic infiltrate. [1]

Nasopharyngeal-type undifferentiated carcinomas most frequently harbor alterations in TP53, TGFBR2, SETD2, PPM1D, and PIK3CA [2].

Most Commonly Altered Genes in Nasopharyngeal-Type Undifferentiated Carcinoma

TP53 c.217-c.1178 Missense, TP53 R158L, TP53 Mutation, TP53 Missense, and TP53 Exon 5 Mutation are the most common alterations in nasopharyngeal-type undifferentiated carcinoma [2].

Top Alterations in Nasopharyngeal-Type Undifferentiated Carcinoma

Disease Details

Nasopharyngeal Type Undifferentiated Carcinoma, Lymphoepithelial Carcinoma, Lymphoepithelioma, Lymphoepithelioma-Like Carcinoma, Schminke Tumor
Large Cell Carcinoma
Lymphoepithelioma-Like Lung Carcinoma, Nasopharyngeal Undifferentiated Carcinoma, and Oropharyngeal Undifferentiated Carcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.