Overview

NCI Definition: A provisional entity describing precursor lymphoid neoplasms that express CD56 and immature T-cell markers, lack B-lymphoid and myeloid markers, and have the immunoglobulin and T-cell receptor genes in the germline configuration. [1]

Natural killer cell lymphoblastic leukemia/lymphomas most frequently harbor alterations in TYK2, TET2, STAT3, NSD1, and FAT1 [2].

Most Commonly Altered Genes in Natural Killer Cell Lymphoblastic Leukemia/Lymphoma

TYK2 P1181L, TYK2 Mutation, TET2 R1216*, TET2 Nonsense, and TET2 Mutation are the most common alterations in natural killer cell lymphoblastic leukemia/lymphoma [2].

Top Alterations in Natural Killer Cell Lymphoblastic Leukemia/Lymphoma

Significant Genes in Natural Killer Cell Lymphoblastic Leukemia/Lymphoma

ABL1 +

AFF1 +

BCR +

CBFA2T3 +

CREBBP +

DEK +

ELL +

ETV6 +

FLT3 +

GLIS2 +

HOXA9 +

KAT6A +

KDM5A +

KMT2A +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

NRIP3 +

NSD1 +

NUP214 +

NUP98 +

PBX1 +

RPN1 +

RUNX1 +

TCF3 +

TP53 +

WT1 +

Disease Details

Synonyms
NK Lymphoblastic Leukemia/Lymphoma, NK-Lymphoblastic Leukemia/Lymphoma, NK-ALL/LBL, Precursor NK Cell Lymphoblastic Leukemia/Lymphoma, Precursor Natural Killer Cell Lymphoblastic Leukemia/Lymphoma, Natural Killer Cell(NK) Lymphoblastic Leukemia/Lymphoma, NK Cell Lymphoblastic Leukemia/Lymphoma
Parent(s)
Precursor Lymphoid Neoplasm
OncoTree Name
Natural Killer (NK) Cell Lymphoblastic Leukemia/Lymphoma
OncoTree Code
NKCLL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.