Diseases /
Natural Killer Cell Lymphoblastic Leukemia/Lymphoma
Overview
NCI Definition: A provisional entity describing precursor lymphoid neoplasms that express CD56 and immature T-cell markers, lack B-lymphoid and myeloid markers, and have the immunoglobulin and T-cell receptor genes in the germline configuration. [1]
Natural killer cell lymphoblastic leukemia/lymphomas most frequently harbor alterations in TYK2, TET2, STAT3, NSD1, and FAT1 [2].
TYK2 P1181L, TYK2 Mutation, TET2 R1216*, TET2 Nonsense, and TET2 Mutation are the most common alterations in natural killer cell lymphoblastic leukemia/lymphoma [2].
Significant Genes in Natural Killer Cell Lymphoblastic Leukemia/Lymphoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.