Overview

NCI Definition: A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias. [1]

Neoplasms most frequently harbor alterations in TP53, KRAS, PIK3CA, CDKN2A, and APC [2].

Most Commonly Altered Genes in Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in neoplasm [2].

Top Alterations in Neoplasm

Disease Details

Parent(s)
Disease or Disorder
Children
Hematopoietic and Lymphoid System Neoplasm, Neoplasm by Site, Benign Neoplasm, Skin Neoplasm, Eye Neoplasm, Esophagogastric Neoplasm, Neoplasm by Morphology, Papillary Neoplasm, Reproductive System Neoplasm, Solid Neoplasm, and Neoplasm by Special Category

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.