Overview

NCI Definition: A neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation. [1]

Neuroblastomas most frequently harbor alterations in MYCN, ALK, ATRX, RPTOR, and CD79B [2].

Most Commonly Altered Genes in Neuroblastoma

MYCN Amplification, ALK Mutation, ALK Missense, ATRX Mutation, and SOX9 Amplification are the most common alterations in neuroblastoma [2].

Top Alterations in Neuroblastoma

Significant Genes in Neuroblastoma

ABL1 +

AFF1 +

ALK +

ARAF +

BCR +

BRAF +

CRKL +

DEK +

ELL +

FLT3 +

HRAS +

KMT2A +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYC +

MYCN +

NF1 +

NRAS +

NUP214 +

RAF1 +

RPN1 +

SRC +

TP53 +

Disease Details

Synonyms
NEUROBLASTOMA, MALIGNANT, Neural Crest Tumor, Malignant, Neuroblastoma (Schwannian Stroma-Poor)
Parent(s)
Neuroblastic Tumor
Children
Ganglioneuroblastoma, Central Nervous System Neuroblastoma, Extracranial Neuroblastoma, and Differentiating Neuroblastoma
OncoTree Name
Neuroblastoma
OncoTree Code
NBL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.