Associated Genetic Biomarkers

Overview

NCI Definition: A neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation. [1]

Neuroblastomas most frequently harbor alterations in MYCN, ALK, ATRX, RPTOR, and CD79B [2].

Most Commonly Altered Genes in Neuroblastoma

MYCN Amplification, ALK Mutation, ALK Missense, ATRX Mutation, and SOX9 Amplification are the most common alterations in neuroblastoma [2].

Top Alterations in Neuroblastoma

Significant Genes in Neuroblastoma

ABL1 +

AFF1 +

ALK +

ARAF +

ATM +

ATR +

BARD1 +

BCR +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

CDK4 +

CDK6 +

CHEK1 +

CHEK2 +

CRKL +

DEK +

EGFR +

ELL +

ERBB2 +

ERBB4 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FLT3 +

HRAS +

KMT2A +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCPH1 +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MRE11A +

MYC +

MYCN +

NBN +

NF1 +

NRAS +

NUP214 +

PALB2 +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAF1 +

RPN1 +

SLX4 +

SRC +

TP53 +

Disease Details

Synonyms
Neuroblastoma (Schwannian Stroma-Poor), Neural Crest Tumor, Malignant, NEUROBLASTOMA, MALIGNANT, PEDIATRIC Soft tissue neuroblastoma
Parent(s)
Neuroblastic Tumor
Children
Extracranial Neuroblastoma, Ganglioneuroblastoma, Central Nervous System Neuroblastoma, and Differentiating Neuroblastoma
OncoTree Name
Neuroblastoma
OncoTree Code
NBL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.