Diseases /

Neuroendocrine Carcinoma

Back to Diseases List
Associated Genetic Biomarkers

Overview

NCI Definition: A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma. [1]

Clinical Trials

View Clinical Trials for Neuroendocrine Carcinoma

Significant Genes in Neuroendocrine Carcinoma

BRCA1 +

BRCA2 +

EGFR +

RET +

RICTOR +

Disease Details

Synonyms
Neuroendocrine Cell Carcinoma, Low-grade neuroendocrine carcinoma, Neuroendocrine cancer, NOS, Metastatic neuroendocrine carcinoma, Poorly Differentiated Neuroendocrine Carcinoma, NEC, CARCINOMA, NEUROENDOCRINE CELL, MALIGNANT, Poorly Differentiated Carcinoma with Neuroendocrine Features, Metastatic high-grade poorly differentiated neuroendocrine carcinoma
Parent(s)
Neuroendocrine Neoplasm
Children
Cervical Neuroendocrine Carcinoma, Ovarian Neuroendocrine Carcinoma, Gastric Neuroendocrine Carcinoma, Esophageal Neuroendocrine Carcinoma, Large Cell Neuroendocrine Carcinoma, Anal Canal Neuroendocrine Carcinoma, Extrahepatic Bile Duct Neuroendocrine Carcinoma, Prostate Neuroendocrine Carcinoma, Neuroendocrine Carcinoma, NOS, Neuroendocrine Carcinoma of Unknown Primary, Endometrial Neuroendocrine Carcinoma, Head and Neck Neuroendocrine Carcinoma, Thymic Neuroendocrine Carcinoma, Colorectal Neuroendocrine Carcinoma, Thyroid Gland Medullary Carcinoma, Pancreatic Neuroendocrine Carcinoma, Vaginal Neuroendocrine Carcinoma, Merkel Cell Carcinoma, Lung Neuroendocrine Carcinoma, Small Cell Carcinoma, and Breast Neuroendocrine Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.