NCI Definition: A benign or malignant neoplasm composed of cells of neuroendocrine origin. Representative examples include paraganglioma, carcinoid tumor, and neuroendocrine carcinoma. [1]

Neuroendocrine neoplasms most frequently harbor alterations in TP53, RB1, KMT2D, RET, and APC [2].

Most Commonly Altered Genes in Neuroendocrine Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, RB1 Mutation, and TP53 Exon 5 Mutation are the most common alterations in neuroendocrine neoplasm [2].

Top Alterations in Neuroendocrine Neoplasm

Disease Details

Well-differentiated neuroendocrine neoplasm, Neuroendocrine Tumor
Endocrine Neoplasm
Uterine Corpus Neuroendocrine Neoplasm, Cervical Neuroendocrine Neoplasm, Neuroendocrine Tumor, Neuroendocrine Carcinoma, Laryngeal Neuroendocrine Neoplasm, Kidney Neuroendocrine Neoplasm, Digestive System Neuroendocrine Neoplasm, Prostate Neuroendocrine Neoplasm, Paraganglioma, Ovarian Neuroendocrine Neoplasm, Breast Neuroendocrine Neoplasm, Thymic Neuroendocrine Neoplasm, Bladder Neuroendocrine Neoplasm, and Lung Neuroendocrine Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.