NCI Definition: A benign or malignant neoplasm composed of cells of neuroendocrine origin. Representative examples include paraganglioma, carcinoid tumor, and neuroendocrine carcinoma. 
Neuroendocrine neoplasms most frequently harbor alterations in TP53, RB1, KMT2D, RET, and APC .
TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, RB1 Mutation, and KMT2D Mutation are the most common alterations in neuroendocrine neoplasm .
There are 3 clinical trials for neuroendocrine neoplasm, of which 3 are open and 0 are completed or closed. Of the trials that contain neuroendocrine neoplasm as an inclusion criterion, 3 are phase 2 (3 open).
Cabozantinib, nivolumab, and atezolizumab are the most common interventions in neuroendocrine neoplasm clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.