NCI Definition: A benign or malignant neoplasm composed of cells of neuroendocrine origin. Representative examples include paraganglioma, carcinoid tumor, and neuroendocrine carcinoma. [1]

Neuroendocrine neoplasms most frequently harbor alterations in TP53, RB1, KMT2D, RET, and APC [2].

Most Commonly Altered Genes in Neuroendocrine Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, RB1 Mutation, and KMT2D Mutation are the most common alterations in neuroendocrine neoplasm [2].

Top Alterations in Neuroendocrine Neoplasm

Disease Details

Neuroendocrine Tumor
Endocrine Neoplasm
Renal Neuroendocrine Tumor, Gastric Neuroendocrine Neoplasm, Cervical Neuroendocrine Neoplasm, Digestive System Neuroendocrine Neoplasm, Thymic Neuroendocrine Neoplasm, Neuroendocrine Tumor, Lung Neuroendocrine Neoplasm, Ovarian Neuroendocrine Neoplasm, Prostate Neuroendocrine Neoplasm, Neuroendocrine Carcinoma, and Paraganglioma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.