Overview

Neuroendocrine tumors most frequently harbor alterations in TP53, RB1, KMT2D, RET, and APC [2].

Most Commonly Altered Genes in Neuroendocrine Tumor

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, RB1 Mutation, and KMT2D Mutation are the most common alterations in neuroendocrine tumor [2].

Top Alterations in Neuroendocrine Tumor

Significant Genes in Neuroendocrine Tumor

BRCA1 +

BRCA2 +

Disease Details

Parent(s)
Neuroendocrine Neoplasm
Children
Carcinoid Tumor, Neuroendocrine Tumor, NOS, Gastrointestinal Neuroendocrine Tumors, and Lung Carcinoid Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.