Overview

Neuroendocrine tumors most frequently harbor alterations in MEN1, TP53, ARID1A, KMT2D, and ATM [2].

Most Commonly Altered Genes in Neuroendocrine Tumor

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, MEN1 Mutation, and KMT2D Mutation are the most common alterations in neuroendocrine tumor [2].

Top Alterations in Neuroendocrine Tumor

Significant Genes in Neuroendocrine Tumor

BRCA1 +

BRCA2 +

Disease Details

Synonyms
Metastatic neuroendocrine tumor, Carcinoid Tumor, Metastatic well-differentiated neuroendocrine tumor, Metastatic neuroendocrine tumor, grade 2, Neuroendocrine Tumor Grade 2, Well-differentiated Neuroendocrine Tumor (Carcinoid Tumor), Neuroendocrine Tumor Grade II, Metastatic well differentiated neuroendocrine tumor, Well differentiated neuroendocrine tumor, Well-Differentiated Neuroendocrine Tumor, Unknown primary neuroendocrine tumor, Metastatic well differentiated EC cell neuroendocrine tumor
Parent(s)
Neuroendocrine Neoplasm
Children
Prostate Well Differentiated Neuroendocrine Tumor, Gastrointestinal Neuroendocrine Tumors, Neuroendocrine Tumor, NOS, Lung Carcinoid Tumor, Bladder Neuroendocrine Tumor, Ovarian Carcinoid Tumor, Renal Neuroendocrine Tumor, Uterine Corpus Carcinoid Tumor, Thymic Carcinoid Tumor, and Breast Neuroendocrine Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.