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Neurofibroma

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Associated Genetic Biomarkers

Overview

NCI Definition: An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple masses. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors. [1]

Clinical Trials

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Significant Genes in Neurofibroma

BRAF +

NF1 +

Disease Details

Synonyms
Neurofibroma (WHO Grade I), Soft tissue neurofibroma, NEUROFIBROMA, BENIGN
Parent(s)
Peripheral Nervous System Neoplasm
Children
Plexiform Neurofibroma, Mediastinal Neurofibroma, Esophageal Neurofibroma, Pacinian Neurofibroma, Cellular Neurofibroma, Epithelioid Neurofibroma, Spinal Cord Neurofibroma, Atypical Neurofibroma, Gallbladder Neurofibroma, and Cardiac Neurofibroma
OncoTree Name
Neurofibroma
OncoTree Code
NFIB

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.