Associated Genetic Biomarkers
NCI Definition: An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple masses. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors. 
Neurofibromas most frequently harbor alterations in NF1, ERBB2, CDKN2A, TP53, and PRKDC .
NF1 Mutation, NF1 Nonsense, ERBB2 Mutation, NF1fs, and ERBB2 V777L are the most common alterations in neurofibroma .
There are 8 clinical trials for neurofibroma, of which 4 are open and 4 are completed or closed. Of the trials that contain neurofibroma as an inclusion criterion, 1 is phase 1 (0 open), 2 are phase 1/phase 2 (1 open), and 5 are phase 2 (3 open).
NF1 is the most frequent gene inclusion criterion for neurofibroma clinical trials .
Aminolevulinic acid, cabozantinib, and photodynamic therapy are the most common interventions in neurofibroma clinical trials.
Significant Genes in Neurofibroma
BRAF is an inclusion eligibility criterion in 1 clinical trial for neurofibroma, of which 0 are open and 1 is closed. Of the trial that contains BRAF status and neurofibroma as inclusion criteria, 1 is phase 1/phase 2 (0 open) .
NF1 is altered in 56.25% of neurofibroma patients .
NF1 is an inclusion eligibility criterion in 7 clinical trials for neurofibroma, of which 3 are open and 4 are closed. Of the trials that contain NF1 status and neurofibroma as inclusion criteria, 1 is phase 1 (0 open), 2 are phase 1/phase 2 (1 open), and 4 are phase 2 (2 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.