Nodal Peripheral T-Cell Lymphoma with TFH Phenotype
Associated Genetic Biomarkers
NCI Definition: A nodal peripheral T-cell non-Hodgkin lymphoma in which the neoplastic lymphocytes manifest a T follicular helper (TFH) cell phenotype. These lymphomas frequently show a diffuse infiltration pattern without a prominent polymorphic inflammatory background, vascular proliferation, or expansion of follicular dendritic cell meshworks. In some cases, a so-called T-zone pattern may be evident. (WHO 2017) 
There is 1 clinical trial for nodal peripheral T-cell lymphoma with TFH phenotype, of which 1 is open and 0 are completed or closed. Of the trial that contains nodal peripheral T-cell lymphoma with TFH phenotype as an inclusion criterion, 1 is phase 3 (1 open).
Oral azacitidine is the most common intervention in nodal peripheral T-cell lymphoma with TFH phenotype clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.