NCI Definition: A nodal peripheral T-cell non-Hodgkin lymphoma in which the neoplastic lymphocytes manifest a T follicular helper (TFH) cell phenotype. These lymphomas frequently show a diffuse infiltration pattern without a prominent polymorphic inflammatory background, vascular proliferation, or expansion of follicular dendritic cell meshworks. In some cases, a so-called T-zone pattern may be evident. (WHO 2017) [1]

Significant Genes in Nodal Peripheral T-Cell Lymphoma with TFH Phenotype


Disease Details

Nodal PTCL with TFH Phenotype, Nodal Peripheral T-Cell Lymphoma with T Follicular Helper Phenotype, Nodal PTCL with T Follicular Helper Phenotype
Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
OncoTree Name
Nodal Peripheral T-Cell Lymphoma with TFH Phenotype
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.